Alcohol consumption promotes tumor progression and elevated serum CCL5 levels, and studies have reported that ethanol increases CCL5 secretion in two CRC cell lines, HT29 and DLD-1, and that CCL5 activates cellular autophagy via the AMPK pathway, further inducing tumor metastasis (65)(Table 1 NO.2). The gene discussed is CCL5; the disease is colorectal carcinoma.