CD8A and colorectal carcinoma: The results of the study used to analyze new methods for secretory immune mediators show that (1) early-stage tumors secrete more IFN-γ compared to advanced-stage tumors, (2) CRC with more type 1 T-cell activity secrete more CXCL10 and CCL5 (type 1 T-cell activity is important for prolonging patient survival (7)), (3) GzmB+ CD8+ T cells are associated with chemokines CXCL10 and CCL5 were positively correlated (75).