Overexpression of IFN-dependent chemokines CCL5 and CXCL10 in CRC cells lacking DNA mismatch repair (d MMR) recruits and activates CD8+ T cells further selectively throughout the body into CRC lacking DNA mismatch repair to further exert anti-tumor immune effects (76)(Figure 1), which are key to the anti-tumor response (Table 1 NO.8). The gene discussed is CCL5; the disease is neoplasm.