The results showed that high levels of CCL5 expression were associated with increased risk of tumor budding (r = 0.583, P < 0.001), deep tumor invasion (r = 0.244, P = 0.001), lymph node metastasis (r = 0.237, P = 0.001), colorectal peri-intestinal nodal deposition (r = 0.198, P = 0.005) and advanced TNM stage (r = 0.256, P < 0.001) were positively correlated (58). This evidence concerns the gene CCL5 and neoplasm.