In mCRC, the immune microenvironment in the invasive margins (Non-central area) of CRC liver metastases whose chemokines recruit CD4+ and CD8+ T lymphocytes into the microenvironment, and infiltrating CD4+ and CD8+ T lymphocytes produce CCL5 has pleiotropic pro-tumor effects on the regulation of tumor cells and tumor-associated macrophages (87)(Figure 2). Here, CD4 is linked to neoplasm.