DHCR7 and prediabetes syndrome: A mendelian randomization study based on three single nucleotide variants associated with 25(OH)D levels: rs2282679, rs10741657, and rs12785878, related to the genes GC, CYP2R1 and DHCR7, respectively, found that a 10% increase in serum 25(OH)D levels causes a 0.3% decrease in eGFR (53), while there was no effect of VitD supplementation of 4,000 IU per day versus placebo for a median duration of 2.9 years on changes in eGFR in adults with prediabetes (54), though there were no data of serum creatinine available in the above two studies.