PNLIP and obesity due to melanocortin 4 receptor deficiency: Phytochemicals exert anti-obesogenic activities by targeting various obesity-related pathways and regulatory functions, including inhibition of dietary lipid digestion through attenuating pancreatic lipase activities, which are considered as main enzymes responsible for the digestion and absorption of lipids, inhibition of adipogenesis and differentiation of preadipocytes, stimulation of existing adipocytes apoptosis (38–43).