Interestingly, most of the modulated genes were shared among some of the important biological pathways identified by IPA analysis; metabolic diseases, inflammatory response, and immune cell trafficking, featuring the role of inflammation in promoting the pathogenesis of obesity [as for S100A8 (49) and CCL2 (50)] and its related comorbidities [as for CD163/CAT and insulin resistance (38, 51), CCL2/IL-10/IFNγ and metabolic syndrome (52–54), MMP2 and hypertension (55), and IL-10 and hypertriglyceridemia (56)], in pediatric population. Here, S100A8 is linked to obesity due to melanocortin 4 receptor deficiency.