EDN1 and cardiovascular disorder: The increase in cardiovascular disease in aging is partly due to vascular endothelial cell senescence and associated vascular dysfunction, and aging is also often accompanied by vascular endothelial cell aging, so we selected 5 key indicators of vascular endothelial function (NO, ET-1, AngII, VEGF, VK2) to aid in the assessment of aging (12, 15).