PLK2 and cancer: Interestingly, these genes were critical components of phase I/II metabolism (CYP1A5, CYP2H1, CYP2K1, CYP2F3, etc), antioxidant enzymes (GST1/3/K1), fatty acid metabolism (ACAA1, ACOX1, ACAT1, FADS1, FASN, HADH, etc), apoptotic genes (CASP3, CBR1, CCBL1, PPIF, KRT18, etc), protein kinases (PLK2), oxidative responsive genes (AKR1A1, AR, AO, FMO3, GPX4, NQO1, TXN, TDO2, etc), cell cycles and cancer-associated genes (PRELID1, PLK2, UGT1A8, MDM2) (308).