In conclusion, paternal pre-conceptional n-3 PUFA supplementation reduced anxiety- and depressive-like behaviors, and improved sociability, learning and memory in offspring, along with alterations in brain structural development and mitochondria, as well as the expression and DMR1 methylation of imprinted-gene Snrpn both in founder mice and their offspring. The gene discussed is SNRPN; the disease is Anxiety.