Another set of curcumin analogs GO-Y078 and GO-Y030 were discovered to be 7 to 12-fold more potent growth inhibitors for myeloma cells, and 6- to 15-fold more powerful suppressors of IRF4, JAK/STAT3, PI3K/AKT, and NF-κB pathways than curcumin (306). The gene discussed is IRF4; the disease is plasma cell myeloma.