The treatment of the flavonoids isorhamnetin, genkwanin and acacetin against some breast cancer cell lines decreased the levels of PI3Kγ-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK in them, thus showing their potential as an inhibitor of the PI3K/Akt/mTOR pathway (129). The gene discussed is PIK3CD; the disease is breast cancer.