TP53 and plasma cell myeloma: The pleiotropic molecule curcumin has been shown to induce G1 phase arrest in HL-60 cells and G2/M phase arrest in K562 cells (212), upregulate p21 and inhibit cyclin D1 in ML-2 and OCI-AML5 cells (213), and downregulation of cyclin D1, downregulation MDM2 and increase in p53 in multiple myeloma cell line (214).