These results indicated that CLS inhibited NSCLC cells growth via multiple targets and pathways, especially by inhibiting signal transduction of “Cytokine-cytokine receptor interaction,” “PI3K-Akt signaling pathway” and “MAPK signaling pathway,” while the involvement of the above pathways needs further experimental verifications (Figures 6H,I). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.