EGFR and breast cancer: The combination of epidermal growth factor receptor (EGFR)-chimeric antigen receptor (CAR) NK-92 cells with oncolytic herpes simplex virus (oHSV) can lead to a higher mortality of MDA-MB-231 BC cells and better outcomes of BC mice, indicating that oHSV-1 therapy combined with EGFR-CAR NK-92 cells is promising in treating the brain metastases of BC (Frings et al., 2011; Chen et al., 2016).