XPC and colorectal carcinoma: Paszkowska-Szczur et al. (2015) reported the association between single nucleotide polymorphisms (SNPs) of seven NER genes and CRC risk in the Polish population, which confirmed that variants in XPC rs2228000, ERCC2 rs1799793 and rs238406 might be associated with CRC risk. ERCC5 rs17655 variant related to increased CRC susceptibility in some case-control studies among Polish and Chinese populations (Gil et al., 2012; Su et al., 2019) but not others (Steck et al., 2014; Kabzinski et al., 2015).