Then, EED recruits polycomb repressive complexes 1 (PRC1) directly to the tri-methylated H3K27 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity, indicating a potential role for SELENBP1 as an epigenetic exchange factor in prostate cancer (Cao et al., 2014). This evidence concerns the gene PRC1 and Familial prostate cancer.