SELENBP1 can also inhibit CRC through lipid/glucose metabolic signaling pathways (Ying et al., 2015a) and participate in mitochondrial function in the HCT116 human colorectal carcinoma cell line through cysteine 57 in SELENBP1 (Ying et al., 2015b). The gene discussed is SELENBP1; the disease is colorectal carcinoma.