Using 139 specimens of primary RCC and 59 specimens of control kidney tissues, the mRNA level of SELENBP1 is significantly downregulated in the RCC tissues than in normal adjacent kidney tissues (p < 0.001) and is correlated with pathologic (T-stage and Fuhrman grade), prognostic variables (progression and cancer-specific death) as well as cancer-specific death (log-rank test, p = 0.014) (Ha et al., 2014). The gene discussed is SELENBP1; the disease is cancer.