Colon cancer: In colon cancer, the promoter of SELENBP1 was methylated in both human colon tissues and cell lines (HCT116, SW480, Caco-2, and HT-29 cells), while it was mostly unmethylated in LS174T cells (Pohl et al., 2009). Here, SELENBP1 is linked to malignant colon neoplasm.