CASP8 and neoplasm: From the heat map and boxplot, it can be seen that 12 genes, BAK1, CASP6, CYCS, PLCG1, TP53, CHMP2A, CASP8, GPX4, BAX, CHMP4C, GSDMB, and GSDMA, are highly expressed in tumor tissues, and the remaining 23 genes are highly expressed in normal tissues (Figures 1A,B).