HSPG2 and neoplasm: PLCG1 is a member of the phosphatidylinositol-specific phospholipase C (PLC) family that hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate inositol 1,4,5-trisphosphate and diacylglycerol (DAG), which is associated with the proliferation and invasion of tumor cells.