Some of GLI2 targets exist within the list of male URGs, including ABCG1, ARRDC2, C19orf33, COL5A1ARE, FZD2, GJB2, ITPR3, LY6E, MMP11, NDC80ARE, NHSX, PALLDARE, and WNT2. In addition, based on the TCGA data source, it seems that GLI2 expression is slightly higher in male PC patients in comparison with the female patients (Supplementary Figure S4). The gene discussed is WNT2; the disease is pachyonychia congenita.