FAM13A and chronic obstructive pulmonary disease: Karimi et al. (2019) Moreover, another study found that FGFR2 and MGAT5 genetic polymorphisms were correlated with the risk of COPD in the Chinese people. (Li et al., 2021). Zhang et al. suggested that a new variant rs17014601 of FAM13A could increase the risk of COPD in Chinese population. Zhang et al. (2018) Base on above results and studies, we speculated that gene polymorphisms play an important role in the pathological process of COPD.