SATB homeobox 2 and neuregulin 1 were proved to be the upregulated hypermethylated genes involved in the pathogenesis of uterine leiomyoma by activating the WNT/β-catenin and TGF-β pathways (Sato et al., 2019). The gene discussed is SATB2; the disease is Uterine leiomyoma.