The differential genes were further screened by Lasso analysis and support vector machine recursive feature elimination (SVM-RFE) analysis of the training sets GSE33532 and GSE151103, and verified by ROC curve analysis, which revealed that the expression levels of two genes, RNPC3 and RHEBL1, were significantly different in non-small cell lung cancer tissues and controls (Figure 4). Here, RNPC3 is linked to non-small cell lung carcinoma.