Polyphyllin VI have been found to be effective in the treatment of non-small cell lung cancer through the p53 pathway and death receptor pathway (Lin et al., 2015), the ROS/NF-κB/NLRP3/GSDMD signaling axis, and the mTOR signaling pathway (Teng et al., 2019). This evidence concerns the gene NLRP3 and non-small cell lung carcinoma.