Polyphyllin VI have been found to be effective in the treatment of non-small cell lung cancer through the p53 pathway and death receptor pathway (Lin et al., 2015), the ROS/NF-κB/NLRP3/GSDMD signaling axis, and the mTOR signaling pathway (Teng et al., 2019). Here, NFKB1 is linked to non-small cell lung carcinoma.