CIH, a key characteristic of OSA, might result in renal disease via its potential association with inflammation, increased sympathetic nervous system activity, activation of the renin–angiotensin–aldosterone system, intrarenal hypoxia, and oxidative stress (Turek et al., 2012; Hanly and Ahmed, 2014; Lu et al., 2017). The gene discussed is REN; the disease is kidney disorder.