During ICD, CALR is exposed on the surface of the cell membrane and acts as an “eat me” signal that promotes the engulfment of dying tumor cells by dendritic cells or their precursors and CALR is normally localized in the endoplasmic reticulum (ER), although it would translocate to the surface of the cell membrane under stress (Gardai et al., 2005; Fucikova et al., 2020). The gene discussed is CALR; the disease is neoplasm.