Moreover, key signaling pathways involved in inflammation and cancer, NOD-like receptor and JAK-STAT signaling pathways, were also highly enriched in ICD cluster A. Chemokine signaling pathways and leukocyte trans-endothelial migration pathways that regulate the TME by coordinating immune cell trafficking tropism were also enriched in ICD cluster A (Supplementary Figure S2A; Supplementary Table S7). This evidence concerns the gene SOAT1 and cancer.