According to the KEGG analysis, the far more significantly enriched pathways engaged Proteoglycans in cancer, PI3K-Akt signaling pathway, Protein digestion and absorption, AGE-RAGE signaling pathway in diabetic complications, Relaxin signaling pathway, Focal adhesion, Human papillomavirus infection, ECM-receptor interaction, Amoebiasis, and Complement and coagulation cascades (Figure 12E, Supplementary Table S8). The gene discussed is RENBP; the disease is amebiasis.