However, they did not find the difference in apoptosis between the esophageal cancer cells with MAGE-D1 knocked out and the control group (Yang et al., 2014), and other researchers also found that MAGE-D1 has no effect on apoptosis (Wen et al., 2004; Xue et al., 2005; Du et al., 2009). This evidence concerns the gene MAGED1 and esophageal cancer.