INS and cancer: KEGG analysis showed that the up-regulated genes were significantly enriched in biological processes such as cysteine and methionine metabolism, biosynthesis of amino acids, glycine, serine and threonine metabolism, transcriptional misregulation in cancer, vitamin B6 metabolism, metabolic pathways, VEGF signaling pathway, insulin resistance, glycosphingolipid biosynthesis − globo and isoglobo series, endocrine and other factor−regulated calcium reabsorption and so on (Figure 2C).