KAT6A homozygous deletion mice (KAT6A−/− mice) have ventricular septal defects, and more than 50% of individuals with inactivating mutations in KAT6A or its paralog KAT6B present with ventricular septal defects and other congenital heart abnormalities (Vanyai et al., 2015; Bscch et al., 2019). The gene discussed is KAT6B; the disease is ventricular septal defect 1.