Based on the TCGA and GTEx databases, all 10 genes were differentially expressed between tumor tissues and normal tissue, and of these, six genes (FDX1, LIAS, DLD, DLAT, PDHB, and MTF1) were correlated with LGG patient prognosis according to Cox regression analysis (Figures 2A,B) Therefore, six prognostic cuproptosis-related DEGs were identified. The gene discussed is LIAS; the disease is neoplasm.