It has been reported that PDHB exerts an anticancer effect by counteracting oncogenic noncoding RNAs, such as miR-370, miR-363-3p, and miR-146b-5p, in melanoma, glioma, and colorectal cancer, respectively (Wei and Ma, 2017; Zhu et al., 2017; Xu et al., 2018). This evidence concerns the gene PDHB and colorectal cancer.