PNPLA3 and fibrosis: Based on standardized coefficients from ridge regression and unscaled permutation-based importance scores from random forest, four variants were ranked among the top 10 contributors in both methods: rs11240351 GG in contactin 2 (CNTN2), rs1800759 TT (LOC100507053), rs738409 GG (PNPLA3) and rs1801690 CG/GG (APOH), present in 59.0%, 43.6%, 41.0%, and 10.3% of subjects with advanced fibrosis, respectively (Figure 5A).