Strong associations with both liver fibrosis and advanced fibrosis were observed for rs1801690 (APOH) [AORs = 5.26 (1.85–14.95), p = 0.002 and 3.57 (1.08–11.83), p = 0.037], rs10409243 (S1PR2) [AORs = 4.55 (1.60–12.90), p = 0.004 and 5.12 (1.20–21.81), p = 0.027] and rs1800759 (LOC100507053) [AORs = 2.18 (1.28–3.70), p = 0.004 and 2.07 (1.05–4.10), p = 0.036]. The gene discussed is S1PR2; the disease is Hepatic fibrosis.