Finally, as host genetics can contribute to variations in gut microbiome composition (Awany et al., 2018) and it is well-established that the gut microbiome contributes to NAFLD progression, we sought to determine whether gut microbiome changes were associated with any of the 86 AST- and ALT-associated variants in the CCHC, as genotype-microbiome associations may uncover potential mechanisms through which host genetics contribute to increased liver disease risk in this population. Here, GPT is linked to liver disorder.