Increased circulating levels and expression of E-selectin in hepatic and adipose tissues have been associated with NAFLD severity (Simons et al., 2020; Rodrigues et al., 2022) and in vivo studies have demonstrated E-selectin’s contribution to the NASH phenotype (Rodrigues et al., 2022). This evidence concerns the gene SELE and metabolic dysfunction-associated steatohepatitis.