Hepatic damage with high serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), renal impairment evidenced by oliguria, coagulopathy, thrombocytopenia with prolonged coagulation times, and disseminated intravascular coagulation (DIC) also occur depending on the severity of VHFs (Figure 1; Mariappan et al., 2021). This evidence concerns the gene GPT and blood coagulation disease.