Finally, the H1N1 infection mice model demonstrated that HSSD can inhibit the accumulation of inflammation in influenza mice by decreasing the levels of HA and NP, reducing the cell apoptosis and pathological state in the lung, regulating the levels of routine blood parameters, IFN-γ, IL-6, IL-10, MCP-1, MIP-1α, and IP-10, as well as attenuating the mRNA and protein expressions of key targets including TLR4, CD14, MyD88, NF-κB p65, HIF1 α, VEGF, IL17A, and IL6. Here, HIF1A is linked to influenza.