There are multiple targets and multiple signaling pathways of HSSD in treating influenza that was screened out by network pharmacology; we tested the critical two signaling pathways of TLR4/NF-κB p65 signaling pathway and HIF-1α/IL17 signaling pathway, which may fail in confirming the other actual effects of candidate targets and other signaling pathways. The gene discussed is NFKB1; the disease is influenza.