We previously demonstrated that infection with a M. fermentans strain isolated in our laboratory from cells from an HIV-seropositive patients promoted lymphoma in a mouse model and that its DnaK interacts with key cellular proteins, including USP10 and PARP1, to hamper essential pathways related to DNA repair and p53 functions (Zella et al., 2018; Benedetti et al., 2020a). This evidence concerns the gene TP53 and lymphoma.