In the multivariable analysis, independent factors associated with new-onset AF were age ≥75 years (OR 2.09, 95%CI: 1.34–3.26, P = 0.001), NT-proBNP ≥ 2,000 pg/ml (OR 3.63, 95%CI: 2.18–6.04, P < 0.001), LAd ≥ 40 mm (OR 2.37, 95%CI: 1.56–3.59, P < 0.001), and primary PCI (OR 1.89, 95%CI: 1.11-3.19, P = 0.018). This evidence concerns the gene NPPB and atrial fibrillation.