TNF and Alzheimer disease: Not surprisingly, inflammatory terms were highlighted in our GO and KEGG enrichment analyses, including “Inflammatory response,” “-positive regulation of TNF production,” “neutrophil chemotaxis,” “Chemokine signaling pathway,” and “MAPK signaling pathway.” Using transgenic mice, Qiu et al. (38) disclosed that in SMCs, Sirt3 plays a protective role in AD by reducing ROS production, vascular inflammation, and apoptosis.