Type I-interferons (TI-IFNs), i.e., interferon-alpha (IFNα) and interferon-beta (IFNβ), are immunomodulatory cytokines typically involved in antiviral responses, which also modulate bacterial or fungal infections (Bogdan et al., 2004; McNab et al., 2015). This evidence concerns the gene IFNB1 and fungal infectious disease.