IFNAR blockade by anti-IFNAR antibodies (Figure 8A) decreased the LPS-induced upregulation of mRNA encoding several ISG, including Cxcl10, which targets Th1 lymphocytes and is involved in sepsis-associated kidney injury and other kidney disease conditions (Herzig et al., 2014; Gao et al., 2020) (Figure 8B). Here, CXCL10 is linked to kidney disorder.