Furthermore, hyperactivation of the TI-IFN pathway and collapsing glomerulopathy has been described in STING-associated vasculopathy with onset in infancy (SAVI), an autoinflammatory disease resulting from gain-of-function TMEM173/Sting mutations (Abid et al., 2020). This evidence concerns the gene IFNA1 and STING-associated vasculopathy with onset in infancy.