Therefore, TWEAK/Fn14 axis blockade decreases kidney inflammation and injury in acute kidney injury (AKI) and autosomal dominant polycystic kidney disease (ADPKD) (Sanz et al., 2008; Martin-Sanchez et al., 2018; Cordido et al., 2021). The gene discussed is TNFRSF12A; the disease is autosomal dominant polycystic kidney disease.