The activation of NLRP3 inflammasome were reported to relating with a wide range of diseases, such as type 2 diabetes, Alzheimer’s disease, obesity, cerebral and myocardial ischemic diseases, and a variety of auto-immune and auto-inflammatory diseases (Fusco et al., 2020). Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.