Deguelin, a natural rotenoid, is among the class of bioactive metabolites from a diverse range of plants with potential antineoplastic effects in different cancer subtypes, deguelin has been reported to inhibit tumor growth via different signaling pathways, including caspase-3, caspase-8, and caspase-9 (Tuli et al., 2021). The gene discussed is CASP3; the disease is cancer.