(TTM), a traditional Chinese medicine, possesses potent anti-tumor effect and polyphyllin VI (PPVI) was successfully isolated from TTM with guidance of the anti-proliferative effect in A549 cells, the mechanism study found that the activity of mTOR which regulates cell growth, proliferation and autophagy was significantly suppressed by PPVI (Teng et al., 2019). Here, MTOR is linked to neoplasm.