NFKB1 and acute respiratory distress syndrome: NLCs encapsulated by intratracheal administration of DEX have been shown to significantly improve lung function in ALI mice and can inhibit the activation of inflammatory pathways (like NF-κB and MAPK) (Wijagkanalan et al., 2011) while also attenuating neutrophil infiltration and inflammatory cytokine expression (Wijagkanalan et al., 2008).