Gated mesoporous silica nanoparticles were surface-coated with a peptide that could target TNFRI expressed in macrophages after encapsulating DEX inside the silica nanoparticles and injecting it into LPS-induced ALI mice via the tail vein, compared with the group treated with DEX injection alone, its controlled release of DEX, and significant reduction levels of inflammatory factors (TNF- α, IL-6, and IL-1β) (García-Fernández et al., 2021). This evidence concerns the gene IL6 and acute respiratory distress syndrome.