Mordes et al. (2005), first mentioned that LEW.1WR1 rats developed fatty liver infiltration. Further research by the group identified increased FAT10 expression in the pancreatic lymph nodes due to a missing short interspersed nuclear element near the promoter region of the gene (Canaan et al., 2014). Recent studies of the livers LEW.1WR1 rats have shown increased glucose intolerance and significant upregulation of FAT10 expression in the livers of the rats (Wilkerson-Vidal et al., 2021). This evidence concerns the gene UBD and Glucose intolerance.