ADCY7 and major depressive disorder: These studies illustrate the possible importance of ADCY7 in fear-related amygdala function, and “conserved changes” in the expression of AC7 transcript in brain tissue from mice used as a model of depressive behavior (Joeyen-Waldorf et al., 2012), and in human subjects diagnosed with MDD, amplify the studies of Hines, et al. (2006).