Assuming that AC7 is mediating the CRF-stimulated ACTH release, and the stress response is of consequence in the etiology of MDD, the sex differences described earlier in the ACTH and glucocorticoid responses in the WT mice, versus those with genetically modified expression of AC7, are notable (Pronko et al., 2010). The gene discussed is POMC; the disease is major depressive disorder.