VDAC2 as a voltage-dependent anion channel was widely explored in multiple FRG prognostic models (Ren et al., 2021; Yi et al., 2021) and bound directly with the ferroptosis activator erastin for increasing the sensitivity of cancer cells to ferroptosis via a FOXM1-Nedd4-VDAC2/3 negative feedback loop in melanoma, (Yang Y. et al., 2020). Here, NEDD4 is linked to melanoma.