K-Ras gene is one of the most popular and well-defined oncogene that mutates in a broad range of solid tumors (Der et al., 1982), including lung adenocarcinoma (∼30%) (Siegfried et al., 1997), pancreatic adenocarcinoma (∼70%–90%) (Visani et al., 2013), stomach cancer (∼10%) (Lee et al., 2003), and colorectal cancer (∼30%–50%) (Andreyev et al., 1998; Downward, 2003). This evidence concerns the gene KRAS and colorectal cancer.