Lgr5 expression in the epithelium and stroma was also closely associated with tumor stage, by integrating functional experiments with Lgr5-sorted cell RNA sequencing data from adenoma and normal organoids, the correlations between Lgr5 and colorectal cancer-specific genes, indicating Lgr5 is an essential marker for studying stem cells in human tissue homeostasis and carcinogenesis (Dame et al., 2018). Here, LGR5 is linked to colorectal cancer.