Nevertheless, in our study, we found that the suppression of G13D mutation promoted major stem markers like CD133, Lgr5, and TGF-β but not others like CD44 and CD24, which were reported as common and important biomarkers for colon cancer by us (Chen et al., 2015) and others (Lee et al., 2015; Ribeiro et al., 2016). Here, LGR5 is linked to malignant colon neoplasm.