Expression of the CSC markers CD44, CD133, and CD166 was induced in intestinal tumours from APC (Min/+)/K-Ras (LA2) mice, but not K-Ras (LA2) mice, indicating that K-Ras mutated cells are more tumorigenic and that APC mutation is required for CSC activation by oncogenic K-Ras mutation (Moon et al., 2014). This evidence concerns the gene APC and intestinal neoplasm.