This herb combination (orally administered at 0.44, 1.31 and 3.93 g/kg) showed anti-migraine effects by adjusting the level of neurotransmitters (5-HT, norepinephrine and dopamine and vasoactive substances (NF-kappaB, nuclear c-fos, inducible nitric oxide synthase, interleukin-1β, and cyclooxygenase-2 levels), consequently relieving neurogenic inflammation (Hou et al., 2017). This evidence concerns the gene NOS2 and migraine disorder.