Besides, AKT has been found to produce a marked effect in muscle atrophy caused by a variety of pathogeny including diabetes type II-related sarcopenia, muscle atrophy induced by cachexia and glucocorticoid (Cetrone et al., 2014; Meng et al., 2022; Mishra et al., 2022). Here, AKT1 is linked to type 2 diabetes mellitus.