A study on C57BL/6J mice suggested that vitamin D deficiency increased the expression levels of MuRF1 and Atrogin-1 protein in the activity-limited gastrocnemius muscle, indicating that vitamin D deficiency resulted in more serious protein degradation of the gastrocnemius muscle during immobilization (Yang et al., 2020). The gene discussed is FBXO32; the disease is vitamin D deficiency.