IL-6-producing myeloid-derived suppressor cells (MDSCs), on the other hand, inhibit CD4+ T cell Th1 differentiation, reducing their capacity to assist CD8+ T cells and dendritic cells, resulting in poorer adaptive immunity against the development of ovarian cancer (Nishio et al., 2014; Luo et al., 2021). The gene discussed is IL6; the disease is ovarian cancer.