Engstrom et al. (2020) discovered that pathological tau protein excluded LSD1 from the nucleus in neurons to cause neuronal cell death, since nuclear LSD1 is required for neuronal survival. In addition, they also demonstrated that the reduction of LSD1 could accelerate the tauopathy phenotype, while the extra supply of LSD1 slowed down the process of neuronal cell death, indicating LSD1 as a critical mediator of pathological tau-induced neurodegeneration (Engstrom et al., 2020). Here, MAPT is linked to tauopathy.