MYB and acute myeloid leukemia: MYB genes contain an N-terminal DNA-binding domain (DBD), a C-terminal negative regulatory domain (NRD) and a central trans-activation domain (TAD) (Figure 2) (Ko et al., 2008); v-myb is derived from mutations in the MYB gene and can cause severe acute myeloid leukemia in vertebrates (Weng et al., 2018; Wang et al., 2020; Smeenk et al., 2021).