Additionally, this study leveraged functional annotations to select and prioritize variants with likely functional consequences on ARRB1 expression for analysis since reduced β-arrestin 1 levels have been previously associated with depression severity and the response to ATD treatment (Avissar et al., 2004; Matuzany-Ruban et al., 2005; Golan et al., 2013). The gene discussed is ARRB1; the disease is Jeune syndrome.