Conversely, the disruption of AKAP5 in E18 embryonic cortical neurons (Mari et al., 2015) (Mari et al., 2015) negatively affect the inhibition of ASIC1a -a ion channel known to be involved in neuropathologies including depression and whose pharmacologic inhibition has antidepressant-like effects (Coryell et al., 2009). The gene discussed is AKAP5; the disease is major depressive disorder.