BDNF and depressive disorder: Prior works in the Cort model of depressive disorder showed that chronic ECS reverses Cort-induced depressive-like phenotype (Schloesser et al., 2015), an effect that may be supported by both rescuing Cort-induced deficit in dendritic spine morphology and increasing expression of Bdnf activity-dependent exons 1 and 6 (Maynard et al., 2018).