Here, we described a main protein network based on 33 proteins involved in three regulatory pathways known to participate in the etiology of mood disorders: glucocorticoid receptor signaling (Cattaneo and Riva 2016; McEwen and Akil 2020), PI3K/Akt signaling (Fujiki et al., 2010; Matsuda et al., 2019) and NRF2-mediated oxidative stress response (Bakunina et al., 2015; Mendez-David et al., 2015). Here, NR3C1 is linked to mood disorder.