Cav3 channels, which comprise three subtypes, Cav3.1, Cav3.2, and Cav3.3, are expressed in neuronal cells where they are activated by small membrane depolarisations and are considered neuronal pacemakers (Cribbs et al., 1998) Dysfunction of Cav3 channels is associated with various medical conditions, including epilepsy, sleep disturbances and pain (Bourinet et al., 2005; Tringham et al., 2012). Here, CAV3 is linked to epilepsy.