ICAM1 and neoplasm: In this study, we reveal that the increased cirGal-3 induced the secretion of intercellular cell adhesion molecule-1 (ICAM-1) in EVs from human umbilical vein endothelial cells (HUVECs), leading to enhance the adhesion of TNBC MDA-MB-231 cells to vascular endothelial cells and promote tumor metastasis.