Indeed, this hub is a dominant regulator of cell fate during intestinal homeostasis, which indicates its crucial role in the pathogenesis of intestinal diseases partly by activating the inflammatory transcription factor nuclear factor kappa Β (NF-κB) (Zhang et al., 2010) and the pro-inflammatory surrogate marker tumor necrosis factor (TNF-α) (Ghorbaninejad et al., 2019). The gene discussed is TNF; the disease is intestinal disorder.