Both act by inhibiting PS1/BACE-1/Aβ, NOTCH1/NICD/HES1, GSK-3β/NF-κB/TNF-α, MDA, & TGF-β1/α-SMA, while boosting PPAR-γ, SMAD-7 to reduce amyloidosis, osidative stress, inflammation, and fibrosis, while amending E-cadherin/β-catenin adherens junction to enhance gut barrier integrity and replenishing goblet cells to protect the colon. Here, NOTCH1 is linked to amyloidosis.