On the other hand, trinitrobenzene sulfonic acid (TNBS)-induced colitis was found to reduce the expression of β2-AR (Fan et al., 2013), and the administration of salbutamol, a β2-AR agonist, has also been found to ameliorate ulcerative colitis (Deng et al., 2022). This evidence concerns the gene ADRB2 and ulcerative colitis.