Indeed, the link between PPAR-γ and the PS1/BACE-1/Aβ trajectory has been highlighted in different AD models, where the increased PPAR-γ decreases Aβ (Camacho et al., 2004) and silences BACE-1 (Kummer and Heneka, 2008). Here, PSEN1 is linked to Alzheimer disease.