TCF7L1 and cancer: Moreover, our exploration of the genetic differences between the cancer lines with strong and weak proliferative response to the derivatives highlighted a set of the Wnt signaling component genes likely responsible for this effect, where TCF7 (a.k.a TCF-1) and TCF7L1 (a.k.a TCF-3) and their immediate regulators and co-factors TLE4 and RUNX3 occupy the central place.