CASP3 and neoplasm: Cleaved caspase-3 participates in the process of cell apoptosis by cutting specific substrates, DNA dependent protein kinases, actin, lamin, etc. Therefore, the high expression of cleaved caspase-3 can induce tumour cell apoptosis, and it is one of the key proteins that promote cell apoptosis (Hou et al., 2015; Manning and Toker, 2017).