Western blot results showed that the inhibitory effect of KPL combined with ABT-199 on the proliferation of hepatoma HepG2 cells may be related to KPL downregulating Mcl-1, thereby regulating the Bcl-2 protein family in the endogenous mitochondrial pathway of ABT-199 regulating apoptosis. This evidence concerns the gene BCL2 and hepatocellular carcinoma.