The result from a follow-up study of 136 patients with DOCK8 deficiency showed that 23 patients (17%) were diagnosed with malignant tumors, including 11 cases of hematological cancer, 9 cases of epithelial cancer and 5 cases of other malignant tumors (Aydin et al., 2015). This evidence concerns the gene DOCK8 and hyperinsulinemic hypoglycemia, familial, 4.