Another study reported that 7 (16.3%) of 43 DOCK8 deficiency patients developed malignant tumors, and the incidence was higher than that of other immunodeficient diseases such as ataxia-telangiectasia and Wiskott-Aldrich syndrome (Cekic et al., 2020). This evidence concerns the gene DOCK8 and hyperinsulinemic hypoglycemia, familial, 4.