DOCK8 mutation and deficiency were detected in the B-cell lymphocytic leukemia patient (Buchbinder et al., 2019) and acute myeloid leukemia (AML) patient, respectively (Kuskonmaz et al., 2017) which implies that DOCK8 deficiency or mutation may contribute to the occurrence of leukemia. The gene discussed is DOCK8; the disease is B-cell chronic lymphocytic leukemia.