DOCK8 mutation and deficiency were detected in the B-cell lymphocytic leukemia patient (Buchbinder et al., 2019) and acute myeloid leukemia (AML) patient, respectively (Kuskonmaz et al., 2017) which implies that DOCK8 deficiency or mutation may contribute to the occurrence of leukemia. Here, DOCK8 is linked to acute myeloid leukemia.